Endocrine Abstracts

Extraadrenal paraganglioma is a rare tumor. The clinical and pathological findings of patients with abdominal localization paragangliomas (perihepatic, paraaortic, interaortocaval and retroperitoneal) are described. Its characteristics and diagnostic imaging are analyzed, as well as its therapeutic management. Between January 2021 and January 2022, 3 patients with extra-adrenal paragangliomas were diagnosed, all of them women. The age of our patients was 26, 57 and 67 years. T...

A 47-year-old male with a history of severe persistent asthma and recurrent respiratory infections with admissions to the Pulmonology Department. The patient underwent a study due to weight loss, diarrhoea and Ca 19.9 elevation. Imaging tests (abdominal CT and MRI cholangio) were performed, which highlighted severe pancreatic fat infiltration. The cystic fibrosis study was completed with genetics (positive: two heterozygous switches F508del and D1152H), sweat test (45 mmol/l -...

Gas chromatography–mass spectrometry (GC–MS) has been used for urinary steroid analysis for over 50 years. The process of hydrolysis to release steroids from their conjugates is routinely performed using commercially available snail Helix-Pomatia sulfatase (HP). However, as this is a naturally occurring enzyme its production process results in batch variation and so each batch requires experimental validation to adjust for the difference in efficiency of the enzymati...

Objective: Vitamin D deficiency has been related to extraskeletal manifestations such as insulin resistance, type 2 diabetes mellitus (DM) and obesity. The objective of this study was to assess the prevalence of vitamin D insufficiency and deficiency in a population of patients with prediabetes and with type 2 DM already established, and to see if there were differences according to different parameters.Material and methods: Cross-sectional study, in whi...

Background: Aggressive prolactinomas are rare neoplasms that are characterized by rapid growth and usually large tumor size, invasion of adjacent structures, an aggressive clinical behavior with little response to conventional treatment, high rate of recurrence, and elevated morbidity and mortality.Case Report: 48-year-old woman diagnosed with life-threatening aggressive prolactinoma was referred to us for evaluation of complementary therapy after therap...

Introduction: Pregnancy is rare in patients with Cushing Disease (CD) owing to ovulatory dysfunction. When surgery is not curative, medical treatment is usually considered. Ketoconazole and mitotane, commonly used medical therapies, have questionable teratogenicity and are not often options in pregnancy. Cabergoline was found to be effective in reducing hypercortisolism in Cushing’s disease. Observational studies suggested that low dose cabergoline treatment at the time o...

Background: Systematic exploration for anterior pituitary deficiency in patients harboring pituitary microadenomas is not well defined. So far, little is known on the involvement of pituitary function in clinically non-functioning pituitary microadenomas (CNFPM).Objective: To evaluate the prevalence of anterior pituitary insufficiency, defined as at least one hormonal deficiency, in patients diagnosed of CNFPM.Patients and methods:...

The experience and expertise of a thyroid surgery team is a relevant factor in the development of postsurgical hipoparathyroidism (hypoPP). In 2005, we published a 9.6% prevalence of permanent hipoparathyroidism among patients operated on for thyroid cancer (TC) at our centre between 1985 and 2001. Since 2002, an expert surgery team was implemented as part of a multidisciplinary committee. The aim of the present study is to assess the prevalence and risk factors associated wit...

Phaeochromocytoma in pregnancy is an extremely rare condition. Early recognition can largely decrease maternal and fetal mortality rates. As symptoms of phaeochromocytoma are similar to those of other more common causes of hypertension during pregnancy, timely diagnosis is a challenge. There is no consensus in literature about the specific treatment nor about the optimal delivery timing or route. Case of a 32 years old woman with a single pregnancy of 30 weeks and 3 days admit...

Background: Multiple endocrine neoplasia type 1 (MEN1) (OMIM 131100) is an autosomal dominant disorder associated with a high risk of developing parathyroid hyperplasia (90%), digestive neuroendocrine tumors (30–70%) and pituitary adenomas (30-40%). Prevalence of MEN1 is 2-10/100.000, there are no differences between men and women and usually, it is diagnosed before 40 years old. It is related to different mutations of the MEN1 tumour-suppressor gene (OMIM: 613733) which ...